The .45-70 and the .44-40are the oldest centerfire cartridges still being loaded by U.S. Ammunition manufacturers and the .45-70 is the oldest centerfire cartridge still being chambered in modern rifles. When loaded with the right bullet, the .45-70 in a modern rifle is perfectly capable of taking any North American game at woods ranges. The 300 and 400 grain flat nose bullets made by Hornady, Sierra, and Speerare excellent choices for deer size game. For elk, moose and bear, 350 grain bullets available from Hornadyand Barnes, and the Speer400 grain flatnose are the right medicine. The .45-70 responds favorably to a variety of powders, including H322, H4198, IMR-3031, and Reloader-7. 

This text is based on information from “Cartridges of the World”, Hodgdon reloading manual, the cartridge designer and/or own resources.