Some say the .375 Holland & Holland Magnum is our all time greatest big game cartridge. Others say it is neither fish nor fowl, too big for deer and too little for really big stuff. But one indisputable fact remains; The .375 H&H; will drop a deer with less meat damage than a .270and has probably accounted for more dangerous game up to the size of Cape Buffalo and elephant than any other large caliber cartridge. Until recently, the .375 H&H; Magnum suffered from lack of bullet variety for handloading, but the reintroduction of the NoslerPartition, the introduction of the SpeerAfrican Grand Slam and BarnesX-Bullets, and the availability of various custom bullets of controlled expansion design has put new life into this old cartridge. When maximum penetration on heavy game such as elephant and Cape Buffalo is desired, the Speer, Hornady, Barnes, and A-Square 300 grain solids are good choices. When shooting elk, moose and the larger African Antelope at relatively long range, the Sierra300 grain spitzer boattail and the Speer250 grain Grand Slam are tough to beat. For bone crushing shots on potentially dangerous, thin skinned game like Brown Bear, and African Lion, bullets of controlled expansion design are the only choices. They would include the NoslerPartition, the Swift A-FRame, and the BarnesX-Bullet. Two excellent powders for Holland's grand old cartridge are H4895 and IMR-4064. 

This text is based on information from “Cartridges of the World”, Hodgdon reloading manual, the cartridge designer and/or own resources.