The 22-250 Remington was adopted early in 1965 as one of the calibers for the Remington 700 series bolt action rifles and also for the Model 40XB match rifle. This is not a factory design, but rather a popular wildcat that has been around for many years and made good. However, Remington's adoption of the round moved into the commercial classification. The 22-250 is one of the best balanced and most flexible of the high powered 22 centerfires. It is also the most popular of the long range 22 varmint cartridges, effective to ranges of 400 yards or more. The 22-250 also has a reputation for outstanding accuracy and has been used with some success for benchrest shooting. The 22-250's, as with most of the other high powered 22's, is not recommended for use on deer or other medium sized game. The reason, of course, is the light varmint bullets are made to expand quickly and will not offer sufficient penetration on a large animal. 

This text is based on information from “Cartridges of the World”, Hodgdon reloading manual, the cartridge designer and/or own resources.